"People think of macrophages as binary (M1 vs. "Macrophages are a heterogenous population, some that are helpful with healing and some that are not," explains Levi. Upon closer examination, the Michigan team found that macrophages are more complex than previously thought-and don't always do what they are supposed to do. Macrophages are white blood cells whose normal job is to find and destroy pathogens. They confirmed that macrophages were among the first responders and might be behind aberrant healing. Using tissue from injury sites in mouse models of heterotopic ossification, they used single cell RNA sequencing to characterize the types of cells present. and Amanda Huber, Ph.D., of the Department of Surgery's section of plastic surgery, took a closer look at the inflammation process in mice. To help explain how the healing process goes awry in heterotopic ossification, the research team, led by Levi, Michael Sorkin, M.D. And while experts suspected that heterotopic ossification was somehow linked to inflammation, new U-M research explains how this happens on a cellular scale-and suggests a way it can be stopped. Patients with heterotopic ossification experience decreased range of motion, swelling and pain.Ĭurrently, "there's no way to prevent it and once it's formed, there's no way to reverse it," says Benjamin Levi, M.D., Director of the Burn/Wound/Regeneration Medicine Laboratory and Center for Basic and Translational Research in Michigan Medicine's Department of Surgery. Heterotopic ossification is abnormal bone formation within muscle and soft tissues, an unfortunately common phenomenon that typically occurs weeks after an injury or surgery. Hip replacements, severe burns, spinal cord injuries, blast injuries, traumatic brain injuries-these seemingly disparate traumas can each lead to a painful complication during the healing process called heterotopic ossification. Office of Graduate and Postdoctoral Studies.Institute for Healthcare Policy & Innovation.Elizabeth Weiser Caswell Diabetes Institute.Computational Medicine & Bioinformatics.Alfred Taubman Medical Research Institute Leadership and Enrichment for Academic Diversity (LEAD).Implicit Bias Training for Community Members.Implicit Bias Training for Michigan Medicine.Health Equity and Quality Scholars Program.Frequently Asked Questions About Sponsorship. About Osher Lifelong Learning Institute.Osher Lifelong Learning Institute (OLLI).Community Outreach and Engagement Programs.
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